Pharmacological characterization of alpha adrenoceptor-mediated motor responses in the rat colon.

ABSTRACT:

Background

Inhibitory neuromuscular transmission in the gastrointestinal tract is mediated by intrinsic nitrergic and purinergic neurons. Purines activate G protein-coupled receptor P2Y₁ receptors, increasing intracellular Ca²⁺ that activates small conductance calcium-activated potassium (SK_Ca) channels. Little is known about the effect of adrenergic receptor activation on intestinal smooth muscle. In vascular tissue, stimulation of α-adrenoceptors causes smooth muscle contraction, while their effect on intestinal tissue is poorly understood. This study aimed to pharmacologically characterize the effect of α-adrenoceptor activation in the rat colon, which shares similar inhibitory pathways to the human colon.

Methods

Muscle bath experiments w

SUBMITTER: Traserra S 

PROVIDER: S-EPMC11650534 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature