The impact of coffee consumption on osteoarthritis: insights from NHANES and Mendelian randomization analysis.

ABSTRACT:

Background

Osteoarthritis (OA) is a prevalent degenerative joint condition, and emerging evidence suggests that dietary factors, such as coffee consumption, may influence its risk. However, the relationship between coffee consumption and the risk of developing OA remains ambiguous. This study aims to explore the association between coffee intake and OA complemented by Mendelian randomization (MR) to infer causality.

Materials and methods

We analyzed data from 32,439 participants across 10 NHANES cycles (1999-2018), including 3,676 individuals diagnosed with OA. Osteoarthritis was diagnosed through a structured questionnaire, while coffee consumption was assessed via 24-h dietary recalls. Participants were categorized based on reported coffee intake: 0 cups, <2 cups, 2-4 cups

SUBMITTER: Feng K 

PROVIDER: S-EPMC11650599 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature