Armored polymyxin B: a nanosystem for combating multidrug-resistant Gram-negative bacilli.

ABSTRACT: Bacterial infections cause high morbidity and mortality worldwide, and the emergence of drug-resistant bacteria further complicates the treatment of infections. Therefore, it is necessary to continuously develop new treatment methods. Polymyxin B (PMB), as the last line of defense, can combat most aerobic Gram-negative bacilli including common drug-resistant bacteria in clinical practice. However, the suboptimal lung tissue concentration of PMB and dose-dependent nephrotoxicity and neurotoxicity limit its clinical application. The nanodrug delivery system offers several key advantages, including high drug loading capacity, excellent biocompatibility, controlled release mechanisms, and targeted delivery. These features enhance the bioavailability of drugs while simultaneously reducing their

SUBMITTER: Huang J 

PROVIDER: S-EPMC11650604 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature