Causal Relationships Between Gut Microbiota, Immune Cell and Pancreatic Cancer: A Two-Step, Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Gut microbiota (GM) is associated with both the occurrence and development of pancreatic cancer (PC), and immune cells potentially play a role in this process. This study sought to evaluate the causative effect of GM on PC and to ascertain possible immune cell mediators.

Methods

The study primarily employed a two-step, two-sample Mendelian randomization (MR) analysis to explore the causal relationship between GM and PC within the European population, placing particular emphasis on the application of the inverse variance weighted (IVW) approach. Additionally, mediation analysis was conducted to explore the potential influence of immune cells as mediators.

Results

The MR analysis revealed a significant association between Geminocystis and the risk of PC. Incr

SUBMITTER: Wang SM 

PROVIDER: S-EPMC11650607 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature