Novel rhodanine-thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach.

ABSTRACT: New rhodanine-thiazole clubbed compounds (7a-7l) were synthesised and characterised with various spectroscopy methods. The synthesised hybrids underwent in vitro HPA, HLAG inhibition, and peroxisome proliferator-activated receptor-gamma (PPAR-γ) expression assays. Through the biological study, compound 7f showed promising inhibitory activity against HPA with an IC₅₀ value of 27.13 ± 1.02 μM and 7l exhibited better inhibition against HLAG with an IC₅₀ value of 24.21 ± 1.12 μM. In addition, Lineweaver-Burk plot analysis suggested that 7l and 7f behaved as a mixed type of HLAG and HPA inhibitor and further, compound 7f showed significant PPAR-γ expression as compared to controls in a dose dependent manner; the expression can be attributed to its mapped pharmacopho

SUBMITTER: Gharge S 

PROVIDER: S-EPMC11650657 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature