Oncogenic accumulation of cysteine promotes cancer cell proliferation by regulating the translation of D-type cyclins.

ABSTRACT: Malignant cells exhibit a high demand for amino acids to sustain their abnormal proliferation. Particularly, the intracellular accumulation of cysteine is often observed in cancer cells. Previous studies have shown that deprivation of intracellular cysteine in cancer cells results in the accumulation of lipid peroxides in the plasma membrane and induction of ferroptotic cell death, indicating that cysteine plays a critical role in the suppression of ferroptosis. Herein, we found that the oncogenic accumulation of cysteine also contributes to cancer cell proliferation by promoting the cell cycle progression, which is independent of its suppressive effect on ferroptosis. The growth ability of four types of cancer cells, including murine hepatocarcinoma cells, but not of primary hepatocytes,

SUBMITTER: Okano Y 

PROVIDER: S-EPMC11650723 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature