Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator.

ABSTRACT:

Background

The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to environmental stimuli, particularly folate status. However, the role of DNA methylation in ZFP57's own regulation has not been fully investigated.

Methods

We used samples and data from our previously described randomised controlled trial (RCT) in pregnancy called Folic Acid Supplementation in the Second and Third Trimester (FASSTT), including follow-up of the children at age 11. Biometric and blood biochemistry results were examined for mothers and children. Methylation of ZFP57 was analysed by EPIC arrays, pyrosequencing and clonal analysis, and transcription

SUBMITTER: Hilman L 

PROVIDER: S-EPMC11650848 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature