Photoredox-catalyzed C(sp³)─H radical functionalization to enable asymmetric synthesis of α-chiral alkyl phosphine.

ABSTRACT: α-Chiral alkyl phosphines are privileged structural motifs with a wide application in organic and medical synthesis. It is highly desirable to develop stereoselective methods to prepare these enantioenriched molecules. The incorporation of C(sp³)─H functionalization and chiral phosphine chemistry is much less explored, probably because of the weak reactivity of C(sp³)─H bonds and/or the challenging site- and stereoselectivity issues. Herein, we disclose a synergistic catalysis system to enable an enantioselective radical addition process of α-substituted vinylphosphine oxides. An array of diverse α-chiral alkyl phosphors compounds is smoothly accessed by using the readily available chemicals as the inert C(sp³)─H bond reagent, such as s

SUBMITTER: Tan Z 

PROVIDER: S-EPMC11650896 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature