Reproducibility of quantitative myocardial perfusion and coronary flow capacity by positron emission tomography: 3D digital silicon photomultiplier solid state vs. legacy 2D analogue systems for clinical practice and trials.

ABSTRACT:

Aims

Quantitative rest-stress myocardial perfusion in millilitres per minute per gram among multiple 2D and 3D positron emission tomography-computed tomography (PET-CT) scanners is essential for personalized cardiac management and clinical trials. Accordingly, this study reports the accuracy and precision of quantitative rest-stress millilitres per minute per gram and coronary flow capacity among 2D and two different digital 3D silicon photomultiplier (SiPM) PET-CT scanners for quantifying the severity of coronary pathophysiology for clinical trials or guiding interventions vs. medical treatment.

Methods and results

One hundred seventy-one participants underwent 748 paired serial rest or stress PET perfusion imaging in the same person on 'same day' or 'different days' using

SUBMITTER: Roby A 

PROVIDER: S-EPMC11651154 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature