Clinical relevance of paramagnetic rim lesion heterogeneity in multiple sclerosis.

ABSTRACT:

Objective

Previous studies reveal heterogeneity in terms of paramagnetic rim lesions (PRL) associated tissue damage. We investigated the physiopathology and clinical implications of this heterogeneity.

Methods

In 103 MS patients (72 relapsing and 31 progressive), brain lesions were manually segmented on 3T 3D-FLAIR and rim visibility was assessed with a visual confidence level score (VCLS) on 3D-EPI phase. Using T1 relaxation time maps, lesions were categorized in long-T1 and short-T1. Lesion age was calculated from time of first gadolinium enhancement (N = 84 lesions). Results on clinical scores were validated in an extended cohort of 167 patients using normalized T1w-MPRAGE lesion values.

Results

Rim visibility (VCLS analysis) was associated with increasing lesional

SUBMITTER: Stolting A 

PROVIDER: S-EPMC11651185 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature