Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats.

ABSTRACT:

Introduction

Smoking increases the risk of lung cancer due to a number of components of smoke. The use of novel heated tobacco products (HTPs), alternative to conventional combustion cigarettes, has increased in recent years. However, the in vivo biological effects of HTPs are poorly understood. This study aimed to clarify the acute effects of injecting aerosol extract prepared from an HTP on regional cerebral blood flow (rCBF) in rat cortex by comparing them to the effects of injecting smoke extract prepared from conventional combustible cigarettes.

Methods

In urethane anesthetized rats, rCBF was measured using laser speckle contrast imaging simultaneously with arterial pressure.

Results

Both cigarette smoke extract and HTP aerosol extract, at a dose equivalent to 30

SUBMITTER: Uchida S 

PROVIDER: S-EPMC11651226 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature