Salivary Proteins and Metabolites as Caries Biomarkers in Adolescents.

ABSTRACT:

Introduction

The identification of salivary molecules that can be associated to dental caries could provide insights about caries risk and offer valuable information to develop caries prediction models. However, the search for a universal caries biomarker has proven elusive due to the multifactorial nature of this oral disease. We have therefore performed a systematic effort to identify caries-associated metabolites and proteins in saliva samples from adolescents that had a caries experience and those that were caries-free.

Methods

Quantification of approximately 100 molecules was performed by the use of a wide range of techniques, ranging from nuclear magnetic resonance metabolomics to ELISA, Luminex or colorimetric assays, as well as clinical features like plaque accumulat

SUBMITTER: Havsed K 

PROVIDER: S-EPMC11651229 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature