Systemic Therapy for Atopic Dermatitis in Children and Adolescents: A US Expert Consensus.

ABSTRACT: Atopic dermatitis (AD) is a chronic, type-2 mediated, inflammatory skin disease characterized by intense pruritus, disruption of skin barrier function, and immune dysregulation. Management strategies for AD are routinely determined based on disease severity. First-line treatment begins with basic skin care and topical anti-inflammatory medication, which is typically sufficient for the management of mild-to-moderate disease. For those patients with moderate-to-severe disease, systemic therapy is often required. This can involve off-label treatment with conventional immunosuppressant medications. However, this approach is limited by a lack of robust clinical trial data and safety concerns that necessitate close monitoring. The emergence of novel targeted biologics and small molecules to trea

SUBMITTER: Eichenfield LF 

PROVIDER: S-EPMC11651338 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature