Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.

ABSTRACT:

Background

Though epidemiological studies show increased cardiovascular disease (CVD) risks among individuals with psychiatric disorders, findings on sex differences in comorbidity have been inconsistent.

Methods

This genetic epidemiology study examined the sex-specific association between the genetic risk of 3 psychiatric disorders (major depression [MD], schizophrenia, and bipolar disorder), estimated using polygenic scores (PGSs), and risks of 3 CVDs (atrial fibrillation [AF], coronary artery disease [CAD], and heart failure [HF]) in 345 169 European-ancestry individuals (UK Biobank), with analyses replicated in an independent BioVU cohort (n=49 057). Mediation analysis was conducted to determine whether traditional CVD risk factors could explain any observed sex differen

SUBMITTER: Jiang JC 

PROVIDER: S-EPMC11651350 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature