Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI.

Methods

The Italian Genetic Study of Early-Onset Myocardial Infarction is a cohort study enrolling patients with MI before 45 years. Monogenic variants causing familial hypercholesterolemia were identified, and a coronary artery disease polygenic score (PGS) was calculated. Ten-fold cross-validated Cox proportional hazards models were fitted sequentially including all clinical variables, the PGS, and monogenic variants on the composite outcome of cardiovascular death, recurrent MI, stroke, or revascular

SUBMITTER: Ardissino M 

PROVIDER: S-EPMC11651354 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature