Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease.

ABSTRACT:

Background

Genome-wide association studies identified a 20-Kb region of chromosome 8 (8q24.13) associated with plasma lipids, hepatic steatosis, and risk for coronary artery disease. The region is proximal to TRIB1, and given its well-established role in lipid regulation in animal models, TRIB1 has been proposed to mediate the contribution of the 8q24.13 locus to these traits. This region overlaps a gene encoding the primate-specific long noncoding RNA transcript TRIBAL/TRIB1AL (TRIB1-associated locus), but the contribution of TRIBAL to coronary artery disease risk remains untested.

Methods

Using recently available expression quantitative trait loci data and hepatocyte models, we further investigated this locus by Mendelian randomization analysis.

SUBMITTER: Soubeyrand S 

PROVIDER: S-EPMC11651355 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature