Understanding the Acid-Base Response to Respiratory Derangements: Finding, and Clinically Applying, the In Vivo Base Excess.

ABSTRACT:

Objectives

To evaluate the base excess response during acute in vivo carbon dioxide changes.

Design

Secondary analysis of individual participant data from experimental studies.

Setting

Three experimental studies investigating the effect of acute in vivo respiratory derangements on acid-base variables.

Subjects

Eighty-nine (canine and human) carbon dioxide exposures.

Interventions

Arterial carbon dioxide titration through environmental chambers or mechanical ventilation.

Measurements and main results

For each subject, base excess was calculated using bicarbonate and pH using a fixed buffer power of 16.2. Analyses were performed using linear regression with arterial dioxide (predictor), base excess (outcome), and studies (interaction term). All stud

SUBMITTER: Heldeweg MLA 

PROVIDER: S-EPMC11651497 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature