Effects of cilostazol on cognitive function and dementia risk: A systematic review and meta-analysis.

ABSTRACT:

Background

Cilostazol is an antiplatelet drug and is used for stroke prevention and symptomatic peripheral vascular disease. Studies have reported the effects of cilostazol on cognitive function, but the results are inconsistent and have not been systematically assessed.

Methods

We systematically searched the PubMed, Embase, and Cochrane databases for relevant clinical studies. The primary outcome was the change in Mini-mental State Examination (MMSE) scores from baseline to the last available follow-up. The secondary outcome was dementia risk. Mean differences and 95% confidence intervals (CIs) were calculated for combining MMSE scores, and the pooled odds ratios and 95% CIs were used to calculate the association between use of cilostazol and dementia risk.

Results

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SUBMITTER: Cheng X 

PROVIDER: S-EPMC11651509 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature