The nonpathogenic role of hyponatremia in the onset of osteoporosis: A Mendelian randomization study.

ABSTRACT: The relationship between hyponatremia and osteoporosis is controversial, and it remains unclear if there is a causal link between the two. This study employed a 2-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between hyponatremia and osteoporosis. The instrumental variables were derived from genome-wide association studies conducted in European populations. These included hyponatremia (n = 465,348) as the exposure factor, with genetic summary data for bone mineral density (BMD) at the forearm (n = 8134), femoral neck (n = 32,735), lumbar spine (n = 28,498), and heel (n = 265,627) as outcomes. The inverse variance weighted method did not identify any causal effect of hyponatremia on BMD. Additionally, other methods, such as MR-Egger, weighted

SUBMITTER: Hongxing Z 

PROVIDER: S-EPMC11651510 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature