Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph.

ABSTRACT: Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared treatment for neuropsychiatric disorders with broad potential for new applications, but the neural circuits that are engaged during TMS are still poorly understood. Recordings of neural activity from the corticospinal tract provide a direct readout of the response of motor cortex to TMS, and therefore a new opportunity to model neural circuit dynamics. The study goal was to use epidural recordings from the cervical spine of human subjects to develop a computational model of a motor cortical macrocolumn through which the mechanisms underlying the response to TMS, including direct and indirect waves, could be investigated. An in-depth sensitivity analysis was conducted to identify important pathways, and machine learning

SUBMITTER: Yu GJ 

PROVIDER: S-EPMC11651605 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature