Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses.

ABSTRACT: The ready availability of brain connectome data has both inspired and facilitated the modelling of whole brain activity using networks of phenomenological neural mass models that can incorporate both interaction strength and tract length between brain regions. Recently, a new class of neural mass model has been developed from an exact mean field reduction of a network of spiking cortical cell models with a biophysically realistic model of the chemical synapse. Moreover, this new population dynamics model can naturally incorporate electrical synapses. Here we demonstrate the ability of this new modelling framework, when combined with data from the Human Connectome Project, to generate patterns of functional connectivity (FC) of the type observed in both magnetoencephalography and functional

SUBMITTER: Forrester M 

PROVIDER: S-EPMC11651611 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature