Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis.

ABSTRACT:

Background

Recent interest in understanding cardiomyocyte cell cycle has been driven by potential therapeutic applications in cardiomyopathy. However, despite recent advances, cardiomyocyte mitosis remains a poorly understood process. For example, it is unclear how sarcomeres are disassembled during mitosis to allow the abscission of daughter cardiomyocytes.

Methods

Here, we use a proteomics screen to identify adducin, an actin capping protein previously not studied in cardiomyocytes, as a regulator of sarcomere disassembly. We generated many adeno-associated viruses and cardiomyocyte-specific genetic gain-of-function models to examine the role of adducin in neonatal and adult cardiomyocytes in vitro and in vivo.

Results

We identify adducin as a regulator of sarcomere

SUBMITTER: Xiao F 

PROVIDER: S-EPMC11651639 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature