Dynamic readout of the Hh gradient in the <i>Drosophila</i> wing disc reveals pattern-specific tradeoffs between robustness and precision.

ABSTRACT: Understanding the principles underlying the design of robust, yet flexible patterning systems is a key problem in developmental biology. In the Drosophila wing, Hedgehog (Hh) signaling determines patterning outputs using dynamical properties of the Hh gradient. In particular, the pattern of collier (col) is established by the steady-state Hh gradient, whereas the pattern of decapentaplegic (dpp), is established by a transient gradient of Hh known as the Hh overshoot. Here, we use mathematical modeling to suggest that this dynamical interpretation of the Hh gradient results in specific robustness and precision properties. For instance, the location of the anterior border of col, which is subject to self-enhanced ligand degradation is more robustly s

SUBMITTER: Reyes R 

PROVIDER: S-EPMC11651649 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature