Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics.

ABSTRACT: Continued methodological advances have enabled numerous statistical approaches for the analysis of summary statistics from genome-wide association studies. Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant 'local' genetic correlations can be investigated further using state-of-the-art methodologies for statistical fine-mapping and variant colocalisation. We explored the utility of a genome-wide local genetic correlation analysis approach for identifying genetic overlaps between the candidate neuropsychiatric disorders, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Parkinson's disease, and schizophrenia. The correlation analysis identified several associations bet

SUBMITTER: Spargo TP 

PROVIDER: S-EPMC11651651 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature