The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).

ABSTRACT: Tumorigenesis, like most complex genetic traits, is driven by the joint actions of many mutations. At the nucleotide level, such mutations are cancer-driving nucleotides (CDNs). The full sets of CDNs are necessary, and perhaps even sufficient, for the understanding and treatment of each cancer patient. Currently, only a small fraction of CDNs is known as most mutations accrued in tumors are not drivers. We now develop the theory of CDNs on the basis that cancer evolution is massively repeated in millions of individuals. Hence, any advantageous mutation should recur frequently and, conversely, any mutation that does not is either a passenger or deleterious mutation. In the TCGA cancer database (sample size n=300-1000), point mutations may recur in i out of n patients. T

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11651657 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature