Tooth loss mediates the association between smoking and an increased risk of dementia among older adults: The JAGES prospective cohort study.

ABSTRACT:

Aim

Tooth loss has various causes; however, its cause-specific effects on health outcomes remain unclear. This study evaluated whether the association between past/current smoking and risk of dementia was mediated by tooth loss.

Materials and methods

This 9-year-follow-up prospective cohort study targeted adults aged ≥65 years. Dementia incidence during 2013-2019, smoking status (never, past/current) in 2010 and the number of remaining teeth (≤19, ≥20) in 2013 were the outcome, exposure and mediator, respectively. We used causal mediation analysis to fit the Cox proportional hazards model and estimated the hazard ratio (HR) and 95% confidence interval (CI) of the natural indirect effect (NIE) of smoking on dementia incidence through tooth loss and their mediated proportions.

SUBMITTER: Kusama T 

PROVIDER: S-EPMC11651716 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature