Single-cell analysis reveals a unique microenvironment in peri-implantitis.

ABSTRACT:

Aim

This study aimed to reveal the unique microenvironment of peri-implantitis through single-cell analysis.

Materials and methods

Herein, we performed single-cell RNA sequencing (scRNA-seq) of biopsies from patients with peri-implantitis (PI) and compared the results with healthy individuals (H) and patients with periodontitis (PD).

Results

Decreased numbers of stromal cells and increased immune cells were found in the PI group, which implies a severe inflammatory infiltration. The fibroblasts were found to be heterogeneous and the specific pro-inflammatory CXCL13⁺ sub-cluster was more represented in the PI group, in contrast to the PD and H groups. Furthermore, more neutrophil infiltration was detected in the PI group than in the PD group, and cell-cell c

SUBMITTER: Li J 

PROVIDER: S-EPMC11651718 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature