Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment.

ABSTRACT:

Aim

To identify serum- and salivary-derived inflammatory biomarkers of periodontitis progression and determine their response to non-surgical treatment.

Materials and methods

Periodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT). Participants were classified according to disease progression: P0 (no sites progressed; P1: 1-2 sites progressed; P2: 3 or more sites progressed). Ten salivary and five serum biomarkers were measured using Luminex. Log-transformed levels were compared over time according to baseline diagnosis, progression trajectory and after NSPT. Significant differences were sought using linear mi

SUBMITTER: Teles FRF 

PROVIDER: S-EPMC11651721 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature