Association between periodontal disease and microstructural brain alterations in the Hamburg City Health Study.

ABSTRACT:

Aim

The aim of the PAROBRAIN study was to examine the association of periodontal health with microstructural white matter integrity and cerebral small vessel disease (CSVD) in the Hamburg City Health Study, a large population-based cohort with dental examination and brain magnetic resonance imaging (MRI).

Materials and methods

Periodontal health was determined by measuring clinical attachment loss (CAL) and plaque index. Additionally, the decayed/missing/filled teeth (DMFT) index was quantified. 3D-FLAIR and 3D-T1-weighted images were used for white matter hyperintensity (WMH) segmentation. Diffusion-weighted MRI was used to quantify peak width of skeletonized mean diffusivity (PSMD).

Results

Data from 2030 participants were included in the analysis. Median age was 65

SUBMITTER: Mayer C 

PROVIDER: S-EPMC11651723 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature