Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis.

ABSTRACT:

Background & aims

Chronic viral infections present serious public health challenges; however, direct-acting antivirals (DAAs) are now able to cure nearly all patients infected with hepatitis C virus (HCV), representing the only cure of a human chronic viral infection to date. DAAs provide a valuable opportunity to study immune pathways in the reversal of chronic immune failures in an in vivo human system.

Methods

To leverage this opportunity, we used plate-based single-cell RNA-seq to deeply profile myeloid cells from liver fine needle aspirates in patients with HCV before and after DAA treatment. We comprehensively characterised liver neutrophils, eosinophils, mast cells, conventional dendritic cells, plasmacytoid dendritic cells, classical monocytes, non-classical monocyte

SUBMITTER: Cui A 

PROVIDER: S-EPMC11651724 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature