Prognostic analysis of SYTL4 in acute myeloid leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy. The key problem lies in the complexity of the genome, so that drug resistance and relapse have become the main problems. Recent studies have found an association between synaptotagmin-like 4 (SYTL4) and drug resistance in triple-negative breast cancer and its high expression is correlated with poor prognosis; however, it is unclear whether this gene is associated with the prognosis of AML. This study aimed to investigate the role and action mechanism of SYTL4 in AML.

Methods

We downloaded gene expression profiles and corresponding clinical data from The Cancer Genome Atlas (TCGA) public database and conducted differential and survival analyses using the Limma and survival packages in

SUBMITTER: Xie KY 

PROVIDER: S-EPMC11651733 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature