Prognostic signature detects homologous recombination deficient in glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is a frequent malignant tumor in neurosurgery characterized by a high degree of heterogeneity and genetic instability. DNA double-strand breaks generated by homologous recombination deficiency (HRD) are a well-known contributor to genomic instability, which can encourage tumor development. It is unknown, however, whether the molecular characteristics linked with HRD have a predictive role in GBM. The study aims to assess the extent of genomic instability in GBM using HRD score and investigate the prognostic significance of HRD-related molecular features in GBM.

Methods

The discovery cohort comprised 567 GBM patients from The Cancer Genome Atlas (TCGA) database. We established HRD scores using the single nucleotide polymorphism (SNP) array data a

SUBMITTER: Luo D 

PROVIDER: S-EPMC11651736 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature