Dephosphorylation-related signature predicts the prognosis of papillary renal cell carcinoma.

ABSTRACT:

Background

Phosphorylation-dephosphorylation is one of the most common and critical cellular activities. It is essential for cell cycle control and leads to large changes in protein conformation, which can alter protein function and coordinate multiple functions such as cell metabolism, gene transcription and translation, signaling, growth, differentiation, and apoptosis. Alterations in the phosphorylated proteome have been shown in many cancers. Many phosphatases that catalyze dephosphorylation have been described as oncogenes and tumor suppressors. Papillary renal cell carcinoma (PRCC) is the second most common subtype of kidney cancer, in which most patients diagnosed with PRCC are already in advanced stages with a poor prognosis. It is necessary to identify reliable predictors

SUBMITTER: Feng J 

PROVIDER: S-EPMC11651751 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature