Construction of a disulfidptosis-related lncRNAs signature of the subtype, prognostic, and immunotherapy in neuroblastoma.

ABSTRACT:

Background

Disulfidptosis is an emerging form of regulated cell death distinguished by abnormal disulfide stress and the collapse of the actin network. This study was to construct a prognostic model based on disulfidptosis-related lncRNAs (DRLs) to enhance survival prediction and assess their viability as biomarkers for immunotherapy response in neuroblastoma (NB).

Methods

Transcriptomic and clinical data from NB patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases. DRLs linked to overall survival (OS) were identified using Pearson correlation and univariate Cox regression analyses. Molecular subtypes of NB were determined through consensus clustering. Immune cell infiltratio

SUBMITTER: Fu Y 

PROVIDER: S-EPMC11651765 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature