Copper metabolism-related lncRNAs predict prognosis and immune landscape in liver cancer patients.

ABSTRACT:

Background

Characterized by its high mortality and easy recurrence, hepatocellular carcinoma (HCC) poses significant clinical challenges. The association between copper metabolism and development of cancer has been identified. However, the underlying mechanisms of copper metabolism-related long non-coding RNAs (CMRLs) in HCC remain elusive. To address the gap, our study analyzed the prognostic and immuno-therapeutic value of CMRLs in HCC.

Methods

This research utilized The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) data (n=424) for analysis, applying the "limma" package in R software for differential gene analysis and construction of a prognostic signature. We validated the signature using training and validation groups stochastically divided at a ratio o

SUBMITTER: Luo R 

PROVIDER: S-EPMC11651766 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature