Construction and validation of a novel prognostic model with palmitoylation-related genes for glioblastoma.

ABSTRACT:

Background

Glioblastoma multiforme (GBM), the most prevalent and aggressive primary brain tumor, poses substantial challenges in both treatment and prognosis. Post-translational modifications, like palmitoylation, are known to have critical roles in the development and progression of glioma. Yet, the molecular mechanisms involved in palmitoylation and its prognostic significance in GBM are still not fully understood. This study aimed to explore prognostic biomarkers for GBM based on palmitoylation-related genes and to construct a prognostic risk model.

Methods

The messenger ribonucleic acid (mRNA) expressions data and the clinical information were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to explore palmitoylation-related mechanisms in

SUBMITTER: Qin G 

PROVIDER: S-EPMC11651772 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature