Novel cuprotosis-related gene signature: a prognostic indicator and regulator of the glioma immune microenvironment.

ABSTRACT:

Background

Glioma is a primary malignant brain tumor with a poor prognosis. Glioma-related biomarkers need to be identified to enable the personalized treatment of and predict the prognosis of glioma patients. Cuproptosis is an unusual mechanism of cell death, and is closely associated with disease progression and the immune-microenvironment of the tumor. However, the function of cuproptosis in glioma is still unclear, therefore the aim of this study was to investigate the role of cuproptosis-related genes in gliomas.

Methods

We examined the relationship between cuproptosis and glioma using the clinical and expression data of glioma tumors from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA).

Results

First, we determined the rate of somatic m

SUBMITTER: Gao D 

PROVIDER: S-EPMC11651775 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature