Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma.

ABSTRACT:

Background

Prostate adenocarcinoma (PRAD) is a common male urinary system cancer, and its targeted treatment is difficult. This study aimed to investigate the value of B cell senescence-related genes in PRAD prognosis.

Methods

PRAD sample expression and clinical information were downloaded from The Cancer Genome Atlas (TCGA) Program and Gene Expression Omnibus (GEO) databases, and B cell senescence-related gene sets were obtained from the Genecards library. The prognostic model was constructed by univariate, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analyses of PRAD differentially expressed genes significantly related to B cell senescence. The Kaplan-Meier (K-M) survival curve and receiver operating characteristic (ROC) curve wer

SUBMITTER: Zheng H 

PROVIDER: S-EPMC11651796 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature