ABALON regulates mitophagy and 5-FU sensitivity in colorectal cancer via PINK1-Parkin pathway.

ABSTRACT:

Background

Growing evidence demonstrated that long non-coding RNAs (lncRNAs) are closely related with chemoresistance in colorectal cancer (CRC). Mitophagy serves as an essential factor to maintain the quality of tumor cells. However, it is unclear whether lncRNAs are involved in mitophagy regulation in CRC. The aim of this study is to evaluate whether lncRNAs are involved in regulating mitophagy and chemoresistance in CRC.

Methods

In this study, gain/loss of function was used to analyze the biological function influenced by apoptotic BCL2L1-antisense long non-coding RNA (ABALON). Western blot and JC-1 probe were carried out for detecting mitophagy. Chemosensitivity of CRC cells to 5-fluorouracil (5-FU) was determined using cell counting kit-8 (CCK-8), flow cyt

SUBMITTER: Liu H 

PROVIDER: S-EPMC11651798 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature