Increased expression of <i>HBXIP</i> (<i>LAMTOR5</i>) predicts poor prognosis and is correlated with immune-cell infiltration in glioma.

ABSTRACT:

Background

The poor response of patients with gliomas to existing immunotherapy has resulted in negligible improvement in prognosis. It is widely acknowledged that HBXIP serves as a transcriptional activator implicated in tumorigenesis across various cancer types. However, its specific role within glioma remains unclear. The aim of this study was to determine the association between HBXIP expression and survival and tumor-infiltrating immune cells. In addition, to construct a prognostic model to predict the overall survival (OS) of patients with glioma.

Methods

Transcriptome sequencing data of 325 patients with glioma in the Chinese Glioma Genome Atlas (CGGA) database and 702 patients with glioma in The Cancer Genome Atlas (TCGA) were included for retrospective

SUBMITTER: Shi L 

PROVIDER: S-EPMC11651804 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature