Pan-cancer analysis combined with experimental validation revealed that <i>KTN1</i> is an immunological and prognostic biomarker.

ABSTRACT:

Background

Kinectin 1 (KTN1) is a membrane protein involved in intracellular organelle motility. However, the role of KTN1 in human pan-cancer lacks systematic analysis and evaluation. The aim of this study is to evaluate the expression profile and clinical value in human cancers by performing a pan-cancer analysis of KTN1.

Methods

The expression of KTN1 and its correlation with cancer-associated fibroblasts (CAFs) infiltration were analyzed in TIMER2.0. The survival analysis, pathological stage correlation, and co-expression gene correlation analysis of KTN1 were performed on GEPIA2.0. We investigated the protein expression level of KTN1 in tumors through UALCAN. The cBioportal platform was used to analyze the variation frequency an

SUBMITTER: Ouyang Y 

PROVIDER: S-EPMC11651810 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature