Diffusion-derived vessel density (DDVD) for penumbra delineation in brain acute ischemic stroke: initial proof-of-concept results using single NEX DWI.

ABSTRACT: Neuroimaging is a cornerstone in the diagnosis and treatment decision-making for brain acute ischemic stroke. A rapid and accurate diagnosis is the key, specifically for time-critical reperfusion therapies. Successful reperfusion of salvageable penumbra can reduce the extent of ischemic stroke and thus improve clinical outcomes, whereas reperfusion of irreversibly affected brain tissue is thought to be futile and may result in harm due to the risk of hemorrhagic transformation. For neuroimaging work-up of acute stroke, computed tomography (CT) is more commonly applied than magnetic resonance imaging (MRI), due to the wider availability of CT scanners in emergency settings. However, the CT perfusion readout thresholds to define infarct area remain controversial. Diffusion-weighted (DW) MRI

SUBMITTER: Chen JQ 

PROVIDER: S-EPMC11651923 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature