Evaluation of neostriatum changes in Crohn's disease: a multimodal brain magnetic resonance imaging study.

ABSTRACT:

Background

Abnormalities of neostriatum have been reported to be implicated in Crohn's disease (CD). However, there are few systematic explorations. We aim to explore the changes that occur in the structure and function of the neostriatum and whether these changes are related to the clinical characteristics of CD.

Methods

In this cross-sectional and prospective study, we enrolled 34 CD patients and 31 healthy controls (HCs) for analysis. We performed voxel-based morphometry (VBM) and seed-based functional connectivity (FC) to evaluate the structural and functional changes in the neostriatum. Correlation analysis was used to evaluate the possible relationships between clinical characteristics and neuroimaging findings.

Results

CD patients had significantly increased gr

SUBMITTER: Li P 

PROVIDER: S-EPMC11651968 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature