Voxel-based evaluation for [¹⁸F] Florbetaben brain β-amyloid positron emission tomography of healthy control, mild cognitive impairment, and Alzheimer's disease.

ABSTRACT:

Background

Positron emission tomography (PET) scans are commonly used to diagnose Alzheimer's disease (AD) by detecting β-amyloid (Aβ) deposition in the cortex; however, brain amyloid plaque load (BAPL) scores based on the visual interpretation of experts are highly subjective. In the current retrospective study, voxel-based processing of [¹⁸F] Florbetaben ([¹⁸F] FBB) Aβ PET scans was used to compare images from patients with AD, patients with mild cognitive impairment (MCI), and healthy controls (HCs). The aim of our study was to highlight the gray matter voxels that were higher uptake than white matter and perform group comparison of the numbers of these voxels among AD, MCI and HC subjects.

Methods

This was a cross-sectional study investigating Aβ PE

SUBMITTER: Lee TH 

PROVIDER: S-EPMC11651969 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature