Mean liver density independently predicts therapeutic response and liver-related mortality in patients with primary biliary cholangitis.

ABSTRACT:

Background

Sarcopenia, myosteatosis, and sarcopenic obesity are known to adversely affect nutritional status and quality of life in cirrhotic patients. However, there is limited research on these conditions in individuals with primary biliary cholangitis (PBC). This study aims to identify risk factors for sarcopenia, myosteatosis, and sarcopenic obesity in PBC patients and to investigate their association with therapeutic outcomes and liver-related mortality. Furthermore, this research aims to uncover novel imaging-based risk factors that may influence biochemical response rates and mortality risk.

Methods

In this retrospective study, patients with PBC were enrolled. Sarcopenia and myosteatosis were defined using the third lumbar vertebra (L3) skeletal muscle index (SMI) and

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11651974 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature