Assessment of cerebral perfusion alterations in dementia with Lewy bodies and Alzheimer's disease.

ABSTRACT:

Background

Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are common forms of dementia, characterized by overlapping clinical symptoms. Functional neuroimaging can provide valuable information for precise diagnosis. Our objective was to explore cerebral perfusion alterations in DLB and AD, and to determine which perfusion parameters are helpful in distinguishing DLB and AD.

Methods

A total of 25 DLB patients, 34 AD patients, and 40 normal controls (NC) underwent neuropsychological testing and pseudo-continuous arterial spin labeling (pcASL) for assessing cerebral perfusion [mean cerebral flow (mCBF); arterial transit time (ATT)] indexes. Differences in perfusion indexes among the three groups were analyzed and the family-wise error (FWE) was used for multiple c

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11652026 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature