Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.

ABSTRACT:

Background

Little is known about the precise impaired patterns of white matter (WM) fiber tracts in preschool-aged children with autism spectrum disorder (ASD). Thus, we used diffusion tensor imaging (DTI)-based automated fiber quantification (AFQ) to explore the changes in WM fiber tracts in preschool-aged children with ASD and its correlation with the severity of clinical manifestations.

Methods

A total of 43 pediatric ASD and 42 age- and sex-matched typical developing children were examined with DTI. AFQ was used to quantify 100 nodes of 16 specific WM fiber tracts. The DTI metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), were compared between the two groups. Correlation analysis was performed to ev

SUBMITTER: Wang L 

PROVIDER: S-EPMC11652057 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature