Urine Protein-to-Creatinine Ratio Remains Informative Despite Nonsteady State Serum Creatinine During Acute Kidney Injury.

ABSTRACT:

Introduction

Experts have cautioned that assessment of proteinuria using urine protein-to-creatinine ratios (UPCRs) are not valid during acute kidney injury (AKI) because reduced urine creatinine in the denominator may artificially inflate the ratio. However, there is little empiric data assessing this theoretical concern.

Methods

Here, we retrospectively examined changes in UPCRs measured during episodes of severe AKI and assessed whether the magnitude and direction of these changes associate with how the serum creatinine level is changing at the time of UPCR collection. We repeated these analyses comparing hospitalization UPCRs with prehospitalization or posthospitalization UPCRs, where available.

Results

Among 329 adults hospitalized with stage 2 or 3 AKI (defined

SUBMITTER: McCoy IE 

PROVIDER: S-EPMC11652066 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature