Clinicopathological Characteristics and Kidney Outcomes in Biopsy-Confirmed Acute Interstitial Nephritis.

ABSTRACT:

Introduction

Acute interstitial nephritis (AIN) is a significant cause of acute kidney injury, with varying etiologies and outcomes. This study aimed to examine the causes, clinical characteristics, management, and kidney outcomes in patients with biopsy-confirmed AIN.

Methods

A retrospective review was conducted on 166 patients diagnosed with AIN through kidney biopsy at Mayo Clinic between 2012 and 2023. Demographic, clinical, laboratory, and pathological data were collected. The primary outcome was kidney function recovery within the first 6 months. Statistical analyses included univariable and multivariable logistic regression, Kaplan-Meier survival analysis, and Cox proportional hazards modeling.

Results

Medications were the primary cause of AIN (67%), followed b

SUBMITTER: Miao J 

PROVIDER: S-EPMC11652094 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature