Long-Term Kidney Outcome of Lupus Nephritis by Renal Response Status.

ABSTRACT:

Introduction

Limited evidence exists that clinical trial treatment response criteria predict long-term outcomes in Asian patients with lupus nephritis (LN).

Methods

This retrospective analysis of prospectively collected data from the Hong Kong Queen Mary Hospital Cohort categorized adults with biopsy-proven LN (Class III, IV, V, or mixed [III ± V, IV ± V]) after standard treatment for 2 years postbiopsy and immunosuppression induction according to modified primary efficacy renal response (mPERR: estimated glomerular filtration rate [eGFR] ≥ 60 ml/min per 1.73 m² or ≤ 20% below biopsy value AND urine protein-to-creatinine ratio [uPCR] ≤ 0.7) and modified complete renal response (mCRR; eGFR ≥ 90 ml/min per 1.73 m² or ≤ 10% below biopsy value AND uPCR ≤ 0.

SUBMITTER: Yap DYH 

PROVIDER: S-EPMC11652096 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature